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Curcumin is a kind of yellow pigment, a extract
from turmeric rhizome.In medical, anticancer is one of the main pharmacological
activities of curcumin.Its capacity to inhibition of tumor has been multiple demonstrated
in the animal tests.A new research states its benefits of other hand.The following is the general:
Cadmium (Cd) exposure can induce acute
lethal health-related threats to humans since it has an exceptional ability to
accumulate in living organisms and cause toxicological effects. Curcumin (Cur)
on the other hand has a wide variety of biological activities and several
animal studies have suggested for a potential therapeutic or preventive effects
against several ailments and infections. To study the effect of Cur on the
toxicity of Cd, sixty Swiss-Webster strain male mice were divided into 6 groups
of ten each at random. Group-1 served as the na?ve control and received no
treatment. Group-2, 3 and 4 were the experimental controls and were
administered once a day with a single oral dose of 50% dimethyl sulphoxide
(DMSO), Cur (300 mg/kg) or Cd (100 mg/kg) respectively, for 2 weeks. Group-5
and 6 received Cur and Cd in combination once a day orally for 2 weeks except
that Cur in a dose of 150 and 300 mg/kg to group 5 and 6 respectively, was administered
one hour before Cd (100 mg/kg) administration to both groups. After treatment
period, the animals were subjected to behavioral tests and thereafter, the
animals were sacrificed for the estimation of neurotransmitters like serotonin
(5-HT), dopamine (DA) and it’s metabolite 3,4-dihydroxyphenylacetic acid
(DOPAC) as well as oxidative stress enzymes like lipid peroxides in the form of
thiobarbituric acid–reactive substances (TBARS) and total glutathione (GSH) in
the forebrain tissue. Cd reduced significantly the body weight gain, the
locomotor activity, anxiety behavior in the plus maze and the learning
capability (cognitive effect) in the shuttle-box test. Biochemical analysis
further revealed that Cd exposure significantly altered the brain neurotransmitters
and the oxidative stress enzymes. However, administration of Cur along with Cd
had an ameliorating effect on all the behavioral and biochemical parameters
studied herein and reduced the toxicity of Cd significantly and
dose-dependently. Thus, Cur may be beneficial for anxiety, neuromuscular, and
cognitive problems and protect from Cd intoxication.
(source: scientific research publishing )
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